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Silver diamine fluoride is a topical medicament (drug) used to treat and prevent dental caries (cavities) and relieve dentinal hypersensitivity.〔http://www.ncbi.nlm.nih.gov/pubmed/22924353〕〔http://www.researchgate.net/publication/259246622_The_inhibitory_effects_of_silver_diamine_fluorides_on_cysteine_cathepsins〕 Silver diamine fluoride has been available in many countries including China, Japan, New Zealand, Australia and other for many decades. The product was cleared for sale in the USA in August 2014 by the FDA as a class II medical device for the treatment of dentinal hypersensitivity.〔http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm?ID=K102973〕 ==Clinical evidence== 6 randomized clinical trials document a profound effect in arresting cavities, simply by drying the cavity and then applying this material. 〔Chu CH, Lo ECM, Lin HC. Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentin caries in Chinese pre-school children. Journal of Dental Research. 2002;81(11):767-770.〕 〔Lo EC, Chu CH, Lin HC. A community-based caries control program for pre-school children using topical fluorides: 18-month results. Journal of Dental Research. 2001;80(12):2071-2074.〕 〔Llodra JC, Rodriguez A, Ferrer B, Menardia V, Ramos T, Morato M. Efficacy of silver diamine fluoride for caries reduction in primary teeth and first permanent molars of schoolchildren: 36-month clinical trial. Journal of Dental Research. 2005;84(8):721-724.〕 〔Yee R, Holmgren C, Mulder J, Lama D, Walker D, van Palenstein Helderman W. Efficacy of silver diamine fluoride for Arresting Caries Treatment. Journal of Dental Research. 2009;88(7):644-647.〕 〔Zhi QH, Lo ECM, Lin HC. Randomized clinical trial on effectiveness of silver diamine fluoride and glass ionomer in arresting dentine caries in preschool children. Journal of Dentistry. 2012;40(11):962-967.〕 〔Santos Dos VE, de Vasconcelos FMN, Ribeiro AG, Rosenblatt A. Paradigm shift in the effective treatment of caries in school children at risk. International Dental Journal. 2012;62(1):47-51.〕 〔Zhang W, McGrath C, Lo ECM, Li JY. Silver diamine fluoride and education to prevent and arrest root caries among community-dwelling elders. Caries Res. 2013;47(4):284-290.〕 2 randomized clinical trials document a profound effect in preventing cavities, by application to other surfaces that have cavities. 〔 〔 〔 4 randomized clinical trials document a profound effect in preventing cavities, simply by drying the tooth surface and then applying this material. 〔 〔Tan HP, Lo ECM, Dyson JE, Luo Y, Corbet EF. A randomized trial on root caries prevention in elders. Journal of Dental Research. 2010;89(10):1086-1090.〕 〔Liu BY, Lo ECM, Chu CH, Lin HC. Randomized trial on fluorides and sealants for fissure caries prevention. Journal of Dental Research. 2012;91(8):753-758.〕 〔Monse B, Heinrich-Weltzien R, Mulder J, Holmgren C, van Palenstein Helderman WH. Caries preventive efficacy of silver diammine fluoride (SDF) and ART sealants in a school-based daily fluoride toothbrushing program in the Philippines. BMC Oral Health. 2012;12(1):52.〕 Silver diamine fluoride stains cavities black. A completely darkened cavity is a strong indicator of success. 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Silver diamine fluoride」の詳細全文を読む スポンサード リンク
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